Comparison of Prognosis in Types 1 and 2 Papillary Renal Cell Carcinoma and Clear Cell Renal Cell Carcinoma in T1 Stage

PURPOSE: We compared subtypes of papillary renal cell carcinoma (pRCC; types 1 and 2) and clear cell renal cell carcinoma (ccRCC) in patients with T1-stage RCC to analyze the impact of the subtype on oncological outcomes. MATERIALS AND METHODS: This paper reviewed 75 patients with pRCC and 252 patients with ccRCC at T1-stage from 1998–2012. Thus, we assessed the impact of subtype on oncologic outcomes among patients with T1-stage RCC. We used Kaplan-Meier analysis to estimate the overall survival and recurrence-free survival The median follow-up duration was 95 months (interquartile range, 75.4–119.3 months). RESULTS: The 5-year recurrence-free survivals of pRCC and ccRCC were 95.4% and 97.6%, respectively. pRCC is worse than ccRCC in terms of recurrence-free survival (p=0.008) and there was no significant difference in the overall survival between pRCC and ccRCC (p=0.32). In addition, there was no significant statistical difference between type 1 pRCC and type 2 pRCC in terms of either recurrence-free survival (p=0.526) or overall survival (p=0.701). Age (hazard ratio [HR], 1.069; p < 0.001) and recurrence (HR, 4.93; p < 0.001) were predictors of overall survival. Only tumor size (HR, 1.071; p=0.004) was predictors in the case of cancer specific survival in the multivariate analysis. CONCLUSIONS: Among patients with T1-stage RCC, recurrence after surgery was more common in pRCC than ccRCC. The subtype of pRCC (types 1 and 2) had no impact on the recurrence-free survival or overall survival.

Association of EGFR mutation with histologic subtypes in lung adenocarcinoma / 国际检验医学杂志

Objective To assess the association of epidermal growth factor receptor (EGFR) mutation with histologic subtypes in lung adenocarcinoma .Methods Lung cancer tissues were collected from 3 028 cases of patients with non‐small cell lung cancer , DNA was extracted respectively ,and EGFR gene exons 18 ,19 ,20 and 2l mutations were dectected by ARMS‐PCR amplification . The association of EGFR mutation with histologic subtypes in lung adenocarcinoma was analyzed .Results The mutation rate of EGFR detection was 39 .7% ,most were exon 19 del and exon 21 L858R (proportion 89 .8% );according to the new classification , EGFR gene mutation in infiltrating lesions with micro infiltrating adenocarcinoma and infiltrating adenocarcinoma were different (P<0 .05) .EGFR mutation rates were higher in moderately differentiated lung adenocarcinoma ,degree of differentiation of EGFR mutation rates were statistically different(P<0 .05) .Conclusion The new classification showes a correlation with molecular diag‐nosis ,different subtypes of EGFR mutation rate is different .There is a certain correlation between EGFR gene mutation and the de‐gree of differentiation in adenocarcinoma .

Incidence of epithelial ovarian cancer according to histologic subtypes in Korea, 1999 to 2012 / 부인종양

OBJECTIVE: To investigate trends in the incidence of epithelial ovarian cancer (EOC), according to histologic subtypes, in Korean women between 1999 and 2012. METHODS: Data from the Korea Central Cancer Registry recorded between 1999 and 2012 were evaluated. The incidences of EOC histologic subtypes were counted. Age-standardized incidence rates (ASRs) and annual percentage changes (APCs) in incidence rates were calculated. Patient data were divided into three groups based on age (59 years), and age-specific incidence rates were compared. RESULTS: Overall, the incidence of EOC has increased. Annual EOC cases increased from 922 in 1999 to 1,775 in 2012. In 1999, the ASR was 3.52 per 100,000 and increased to 4.79 per 100,000 in 2012 (APC, 2.53%; p<0.001). The ASRs in 2012 and APCs between 1999 and 2012 for the four major histologic subtypes were as follows (in order of incidence): serous carcinoma (ASR, 2.32 per 100,000; APC, 4.34%; p<0.001), mucinous carcinoma (ASR, 0.73 per 100,000; APC, -1.05%; p=0.131), endometrioid carcinoma (ASR, 0.51 per 100,000; APC, 1.48%; p=0.032), and clear cell carcinoma (ASR, 0.50 per 100,000; APC, 8.13%; p<0.001). In the sub-analyses based on age, clear cell carcinoma was confirmed as the histologic subtype whose incidence had increased the most since 1999. CONCLUSION: The incidence of EOC is increasing in Korea. Among the histologic subtypes, the incidence of clear cell carcinoma has increased markedly across all age groups since 1999.

Distribution of Histologic Subtypes of Basal Cell Carcinoma by Facial Aesthetic Unit and Subunit / 대한피부과학회지

BACKGROUND: Surgical removal and reconstruction in basal cell carcinoma(BCC) located in the face is important both functionally and cosmetically, however, evaluation of clinical and histological characteristics of BCC in view of dermatologic surgery is not enough. OBJECTIVE: To assess the anatomic distribution of primary and recurrent BCCs, and of histological subtypes based on facial aesthetic units and subunits. And to establish their importance and their application to the dermatologic surgery field. METHODS: We reviewed patients' charts to extract clinical data and reexamined their histologic patterns on the excised specimen, classifying then into 5 categories and mapped the anatomical location of the histologic subtype on schematic drawings of the facial the aesthetic unit and subunit. RESULTS: The location of occurrence in BCCs were on the junctional lines, nose, periorbital area respectively. Of 60 cases occurred in H-zone, 48 cases(80%) occurred in T-zone, and of 9 recurrent cancers occurred in H-zone, 7 cases occurred in T-zone. Among the 5 histologic subtypes, the nodular type was the most common on each of the aesthetic units. And in the junctional lines, the nodular type occurred in almost all cases. The nodulomorpheic type occurred relatively more on forehead, nose and infraorbital area of the cheek. CONCLUSION: We confirmed the relationship between the clinical, histological characteristics and facial aesthetic unit and subunit. And we also proved that T-zone was the most dangerous zone.

A STUDY ON THE PROGNOSIS AFTER ENUCLEAT10N IN THE UNICYSTIC AMELOBLASTOMA

Since the apparent development of ameloblastoma in the wall of a dentigerous cyst was first described by Cahn in 1933. many colleagues have reported the ameloblastoma originated odontogenic cyst. In 1970. Vickers and Gorlin published specific histologic criterria of the ameloblastoma originated odontogenic cyst, and in 1977, robinson and Martinez referred to this variant as unicystic ameloblastoma in which the tesponse to encleation or curettage was found to be fanorable with low recurrence rate. This lesion was divided into 3 Groups (luminal, plexiform, connective tissue invasion type) according to the histopathologic feature by Ackeymann etc. in 1988, and they recommended radical treatment In connective tlssue Invasion type. Conservative enucleation and currettge have been reported the choice treatment compared with conventional ameloblastoma. which has represented low recurrent rate, but the study on the prognosis after enucletion according to the histologic subtypes of the unlcystic ameloblastoma has been rare. This study is to invested the recurrence and clinical features of 22 ameloblastomas which have been experienced by enucleation as trearment method from January 1990 to October 1997 in Dental College Hospital of Yonsei University. The results obtained are as follows. 1. The most common patients complains were painless or painful swelling of jaw(19 cases, 86.4%). dysthesia (2 cases, 9.1%), pus discharge (1 case, 4.5%) were next In order. 2. The most frequent age was 2nd decade which was 12 cases(54.5%), and next frequent age was 3rd decade which was 8 cases (36.5%). The average age was 20.5 years old, and sex ratio was 1.4:1 (male female). 3. All 22 cases were developed in the mandible, and body area occupied 15cases (68.2%), ramus area was 6 Cases(27.2%) and symphysis area was 1 case (4.5%). 4. Radiographically, unilocular type was 81.8%, and the cases related with impacted tooth were ular type and 3 cases (75%) In multllocular type. 5. According to histologic subtype by Ackermann's classification, luminal type and were 4case(18.2%) respeclively, connective tissue type was 12 cases (63.6%). 6. Average follow-up period was 3.4 years, and the recurrence was 1 case(4.5%) of total 22 cases, which was connective tissue Invasion type (7.14%) histologically. Based on the above results, when patient's function, esthetics, and paychologic factor are considered,the enucleation was adequarte primary treatment modality In any histologic type of the unlcystic ameloblastoma

Surgical Outcome and Prognostic Factors of Spinal Intramedullary Ependymomas in Adults

Ependymoma is the most common spinal intramedullary tumor in adults. The authors reviewed clinical data of 31 patients with spinal ependymoma who underwent operations between 1979 and 1996. The ages of the patients ranged from 15 to 62 years with a mean of 36.9. We analyzed clinical manifestations, radiologic findings, extents of surgical removal, histologic subtypes and follow-up results. Most patients were presented with sensory symptoms as initial symptoms which had lasted for 36.5 months on the average. The most frequent location was conus region(10 cases, 32%) followed by cervical, thoracic and cervico-thoracic spinal level. All cases were divided into two groups histologically, 12 myxopapillary subtypes and 19 non-myxopapillary subtypes. Operative results were dependent on the locations and the histologic subtypes of the tumor. Total removal was achieved in 4 cases out of 10 cases with masses around the conus and in 19 cases out of 21 cases with masses at other regions(p=0.003). Tumors were totally removed in 97% of 19 non-myxopapillary subtypes, but in 42% of 12 myxopapillary subtypes(p=0.001). From the follow-up data, we found that mean progression free interval was 83 months and 5 year progression free rate was 70%. Extent of removal was the only significant prognostic factor on multivariate analysis. Other factors such as tumor location, histologic subtype and radiation therapy were not significant. Disease progression was noted in 2 cases out of 23 cases of total removal group, but in 4 cases out of 8 cases of incomplete removal group (p=0.008). Postoperative radiation therapy was done in 4 cases in incomplete removal group and tumor regrowth was noted more frequently in non-radiation group than in radiation group without statistic significance. We concluded that disease progression can be determined by the extent of removal which is related to the tumor location and histologic subtypes.